Created more than 70 years ago following the notorious World War II experiments, this written document established 10 ethical principles for protecting human subjects.
What Is the Nuremberg Code?
When World War II ended in 1945, the victorious Allied powers enacted the International Military Tribunal on November 19th, 1945. As part of the Tribunal, a series of trials were held against major war criminals and Nazi sympathizers holding leadership positions in political, military, and economic areas. The first trial conducted under the Nuremberg Military Tribunals in 1947 became known as The Doctors’ Trial, in which 23 physicians from the German Nazi Party were tried for crimes against humanity for the atrocious experiments they carried out on unwilling prisoners of war. Many of the grotesque medical experiments took place at the Auschwitz concentration camp, where Jewish prisoners were tattooed with dehumanizing numbers onto their arms; numbers that would later be used to identify their bodies after death.
The Doctors’ Trial is officially titled “The United States of America v. Karl Brandt, et al.,” and it was conducted at the Palace of Justice in Nuremberg, Bavaria, Germany. The trial was conducted here because this was one of the few largely undamaged buildings that remained intact from extensive Allied bombing during the war. It is also said to have been symbolically chosen because it was the ceremonial birthplace of the Nazi Party. Of the 23 defendants, 16 were found guilty, of which seven received death sentences and nine received prison sentences ranging from 10 years to life imprisonment. The other 7 defendants were acquitted.
The verdict also resulted in the creation of the Nuremberg Code, a set of ten ethical principles for human experimentation.
What Are The Nuremberg Code’s Ethical Guidelines For Research?
The Nuremberg Code aimed to protect human subjects from enduring the kind of cruelty and exploitation the prisoners endured at concentration camps. The 10 elements of the code are:
- Voluntary consent is essential
- The results of any experiment must be for the greater good of society
- Human experiments should be based on previous animal experimentation
- Experiments should be conducted by avoiding physical/mental suffering and injury
- No experiments should be conducted if it is believed to cause death/disability
- The risks should never exceed the benefits
- Adequate facilities should be used to protect subjects
- Experiments should be conducted only by qualified scientists
- Subjects should be able to end their participation at any time
- The scientist in charge must be prepared to terminate the experiment when injury, disability, or death is likely to occur
The Significance Of The Nuremberg Code
The Nuremberg Code is one of several foundational documents that influenced the principles of Good Clinical Practice (GCP).
Good Clinical Practice is an attitude of excellence in research that provides a standard for study design, implementation, conduct and analysis. More than a single document, it is a compilation of many thoughts, ideas and lessons learned throughout the history of clinical research worldwide.
Although there has been updated guidance to Good Clinical Practice to reflect new trends and technologies, such as electronic signatures, these basic principles remain the same. The goal has always been—and always will be—to conduct ethical clinical trials and protect human subjects.
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